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Targeting valine catabolism to inhibit metabolic reprogramming in prostate cancer

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Substantial evidence confirms that gut barrier dysfunction-induced microbial imbalance facilitates bacterial endotoxin (e.g., LPS) translocation across the intestinal epithelium into systemic circulation, precipitating metabolic endotoxemia - a process driving multi-tissue injury through systemic inflammatory responses (Saad et al., 2016)

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It plays a protective role in viral diseases

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