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Tanycyte, the neuron whisperer

Metabolism 2012 , 61 , 14221434

In these contexts, astrocytes may shift from a neuroprotective role to one that exacerbates neuronal dysfunction, potentially due to downregulated expression of lactate dehydrogenase A (LDHA), a key glycolytic enzyme, which impairs lactate shuttling by inhibiting large conductance Ca 2+ activated potassium channel (BK channel)-mediated neuronal hyperpolarization (Yao et al., 2023)

Biliary Copper Excretion Bile is the major physiologic route for eliminating excess copper

Because these come from separate studies with different patient populations (not from SURMOUNT-5), they arent a direct comparison, but they give a useful sense of what to expect on each medication

All supplies, including needles and alcohol swabs, are included