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Additionally, people with kidney or liver disease, iron or folic acid deficiencies or bone marrow-affecting conditions should consult their doctor before using B12 injections[18]

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The higher toxicity results most likely from the overall higher amount of the cationic surfactants within SEDDS 1 compared to SEDDS 3 where the cationic surfactant is complexed in ion pairs and only to a minor extent available at the surface of nanodroplets