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In SURMOUNT-1 (N=2,539), the obesity-dose trial, nausea rates reached 24-31% during the titration phase, though they declined to under 5% by week 20 in most dose groups [8]

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Instead, the smell is almost always an indirect consequence of the profound metabolic shifts that tirzepatide initiates

By contrast, selective serotonin reuptake inhibitors (SSRIs) like Prozac (fluoxetine) and Zoloft (sertraline) affect serotonin, while serotonin and norepinephrine reuptake inhibitors (SNRIs) such as Cymbalta (duloxetine) and Effexor (venlafaxine) boost norepinephrine and serotonin

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