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Semaglutide (Wegovy/Ozempic) is the closest currently available alternative, producing 14-16% average weight loss compared to tirzepatide at 18-22%
Patients are seeking therapies that contribute to weight management and reduce overall cardiometabolic risk, making incretinbased medications a suitable fit for longterm care
For context on managing these effects, the approaches used for GLP-1 constipation and GLP-1 bloating apply here with some modifications
In clinical practice, many bariatric programs include routine B12 injections in their post-surgical nutrition protocols
Concurrent use of buprenorphine, methadone, or naltrexone does not inhibit ketamines antidepressant activity
