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GLP-1 therapy helps regulate insulin, stabilize blood sugar levels, and reduce fat storage, contributing to better energy levels, mood, and overall well-being
Statistical analysis We applied the inverse variance-weighted (IVW) method with a multiplicative random model as the main statistical analysis and performed the following methodologies to test the core assumptions of MR (relevance, exchangeability, and exclusion restriction)
Improves insulin sensitivity, being used in diabetes for the prophylaxis of complications: neuropathy, myopathy, retinopathy, cataracts, glaucoma
SP: Signal peptide
Furthermore, MC4R-deficient mice develop severe obesity accompanied by markedly elevated plasma leptin concentrations and leptin resistance, failing to respond to leptins anorectic and cardiovascular effects [58, 59]
In severe cases, coma or even life-threatening situations may occur
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