Nicotinamide N-Methyltransferase: More than a vitamin B3 clearance enzyme (in Eng)
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When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted
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Longevity pathway activation NAD+ plays a crucial role in activating sirtuins, a family of proteins involved in cellular repair, stress response, and aging
Available from: Haines J, Neumark-Sztainer D