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1A) across a broad range of ages (median female = 52.8, male = 56.9)
LWT, 171, 114116
In aging cells, FOXO4 normally binds to p53, preventing it from triggering programmed cell death
In multiple pathological settings, affected cells are not distributed randomly, but instead form contiguous zones of degeneration, synchronized tubular epithelial loss, aligned myofiber injury, or expanding fronts of tissue damage, patterns that are difficult to reconcile with strictly cell-autonomous execution
J Neuroinflammation 17:18 Zanoni I et al (2011) CD14 controls the LPS-induced endocytosis of Toll-like receptor 4