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In addition, metreleptin requires daily injection, which is painful in lipodystrophic individuals due to the paucity of subcutaneous adipose tissue, is costly and not available to patients in all countries

This is the shared mechanistic theme across the copper-peptide family, with GHK-Cu the most-characterized example (Pickart & Margolina 2018, PMID 29986520)

Moreover, the continuous release of ROS and lipid peroxidation unfavourable influences cerebral blood flow, leading to immunosuppression and brain plasticity (Shohami and Kohen, 2011)

Some suppliers offer AHK-Cu pre-formulated in liposomal carriers at concentrations like 7 or 10 percent

[Article] [PubMed]77

10.1007/s11010-021-04079-4 Mol