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Failure of DNA repair induces apoptosis through p53 activation, mitochondrial pathway induction, and persistent DNA damage response (DDR) signaling 8-10

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Child-Pugh B (moderate impairment, score 7-9)

Operating conditions for the LC-MS/MS are listed in Supplementary Table 3

The theoretical advantage is significant

Given the stresses of preparing for a possible conflict with China in terms of cost, modernisation, readiness and training, etc