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[58] Medical uses [edit] Treatment of deficiency [edit] Severe vitamin B 12 deficiency is initially corrected with daily intramuscular injections of 1000 g of the vitamin, followed by maintenance via monthly injections of the same amount or daily oral dosing of 1000 g

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Substituting these amino acids influenced both the catabolism [49, 52] and neonatal transcytosis [52] of mouse IgG1 fragments in wild-type (WT) mice in a manner that correlated with the binding affinity of the mutated Fc fragments towards mouse FcRn at pH 6.0 [51]