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The analysis could not determine whether GLP-1 agonists directly reduced cancer incidence, nor could it assess medication adherence, dose, treatment duration, cumulative exposure, or the effects of different drug formulations
results vary by baseline pigmentation, UV exposure and adherence to the combined plan
They are different molecules targeting partially overlapping but distinct receptor pathways
Gastrointestinal side effects include: Nausea (very common, affecting more than 1 in 10 people): Often most pronounced during dose escalation, typically improving over time Diarrhoea (very common): Can range from mild to severe and may be difficult to distinguish from a Crohn's flare Vomiting (common, affecting up to 1 in 10 people): May contribute to dehydration and electrolyte imbalance Constipation (common): Paradoxically, some patients experience reduced bowel frequency Abdominal pain (common): Can mimic or exacerbate Crohn's-related pain These effects result primarily from delayed gastric emptying and altered gastrointestinal motility
MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function
