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Transcriptional activation of G6PD in response to oxidative stress is carried out by the transcription factor, NRF2 (nuclear factor erythroid 2related factor 2)

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There are many studies that have examined the link between antioxidants and inflammatory and oxidative pathways

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In this review, we have highlighted studies that demonstrate how NADPH metabolism is altered in activated myeloid cells, and how the competition for NADPH consumption between oxidative and antioxidative pathways reflects a potential way to efficiently regulate the magnitude of inflammation