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The positron emission tomography (PET) was used to examine brain oxygen consumption and cerebral blood flow and revealed that patients with overt hepatic encephalopathy and those with liver cirrhosis without overt hepatic encephalopathy had a lower cerebral metabolic rate of oxygen and cerebral blood flow than healthy subjects 4

It predominantly localizes to the cellular membrane of diverse cell types throughout the human body

Animal models of developmental thyroid hormone deficiency have also reproduced marked neurocognitive impairment and growth retardation in offspring, much like in humans with hypothyroidism (Chaulin et al

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