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Inclusion Criteria The included studies had to meet the following criteria: Studies that reported the combined use of GLP1-RAs and SGLT2is in individuals with T2D were included if they provided a clear description of the study design and well-defined measurements for any outcome relevant to the research questions

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L-carnitine : L-carnitine is a vitamin-like compound that occurs naturally in the body

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PIONEER 1: Randomized Clinical Trial of the Efficacy and Safety of Oral Semaglutide Monotherapy in Comparison With Placebo in Patients With Type 2 Diabetes