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Yet another small molecule that has been studied extensively as a highly potent small molecule inhibitor of both human and murine CD38 is 78c, which has been shown to be 10-fold less potent against the cyclase activity than the hydrolase activity of recombinant human CD38 139

Oxidative stress and psychological disorders

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Digestive discomfort A rare but possible effect in sensitive individuals

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Rushing this process, skipping dose levels, or starting at a higher dose to accelerate weight loss dramatically increases side effect severity