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The initial rapid and short-lived release facilitated by Large Dense Core Vesicles (LDCVs) at the plasma membrane is followed by a sustained release of insulin that depends on the mobilization of insulin-secreting granules (ISGs) to the plasma membrane for exocytosis 1

[7] However, FDA labeling for both semaglutide and tirzepatide includes warnings about acute kidney injury, particularly in patients experiencing severe gastrointestinal adverse effects

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Well analyze the mechanisms behind this connection and offer practical guidance for monitoring patients

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doi: 10.3389/fcimb.2022.1002406 351 SainiV.SafwanS