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Free Radic Biol Med (1998) 24:30517.10.1016/S0891-5849(97)00231-1 12 YangXYaoHChenYSunLLiYMaXet alInhibition of glutathione production induces macrophage CD36 expression and enhances cellular-oxidized low density lipoprotein (oxLDL) uptake
Yet long-term data around GLP-1 medications remains limited, particularly around weight regain
The result in phase 2 clinical trials was 24.2% mean body weight reduction at 48 weeks with the 12mg dose, and the first phase 3 TRIUMPH-4 trial reported an average of 28.7% weight loss at 68 weeks
Brand-name semaglutide (Ozempic and Wegovy) Ozempic (for type 2 diabetes) and Wegovy (for weight management) both contain FDA-approved semaglutide
Wegovy (higher-dose semaglutide, 2.4 mg) is available via NHS specialist weight management clinics for eligible patients, currently BMI 35+ with a weight-related condition, or BMI 30+ in certain clinical pathways
The 86% decrease in liver fat observed with the highest dose is one of the best reported to date
