Just like the other versions of this drug, it does cause some gastrointestinal issues, which are nausea, vomiting, cramping, constipation, and diarrhea
Avoid the inner thigh where blood vessels and nerves are closer to the surface
If you are using semaglutide or tirzepatide and experience signs like sudden leg swelling, chest pain, or shortness of breath, you may be experiencing symptoms of a blood clot, and you should seek immediate medical assistance
It is being studied for the treatment of T2DM, Obesity, Osteoarthritis , and Obstructive Sleep Apnea with a planned simultaneous submission strategy
It may help with cognition, memory, anti-aging, depression, and other conditions
The FDA approved once-daily oral semaglutide (Wegovy) at 25 mg on 22 December 2025, making it the first oral GLP-1 approved specifically for chronic weight management in the US