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105 , 12021214 (2010) Liu, D., Lin, X., Ghosh, D.: Semiparametric regression of multidimensional genetic pathway data: least-squares kernel machines and linear mixed models
doi: 10.1016/j.molmed.2025.02.002
Nature 451, 340344
In a multiple-ascending dose study in NAFLD subjects, about 20% of whom had biopsy-confirmed NASH, weekly or every-other-weekly administration of BIO89-100 for 12 weeks reduced serum triglycerides by 1828%, reduced liver fat by 3660%, and increased adiponectin by 2361% relative to baseline (299)
Barton ER, et al
Story MD, Voehringer DW, Stephens LC, Meyn RE
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