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In addition, the activation of GLP-1R was shown to promote synaptic plasticity and axonal growth (90)

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doi: 10.3389/fnins.2018.00381 Received 28 February 2018 Accepted 18 May 2018 Published 07 June 2018 Volume 12 - 2018 Edited by Victor Tapias, Cornell University, United States Reviewed by Carsten Culmsee, Philipps University of Marburg, Germany

However, if the purpose of the drug is to be taken up by the liver, then first-pass metabolism may be irrelevant (the drug is still metabolized into hepatic glutathione, which is what matters)