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If your disease is very severe or it doesnt respond to one or more TNF inhibitors, your doctor might try a biologic that blocks interleukin-17 (IL-17) or interleukins 12 and 23 (IL 12/23) either secukinumab ( Cosentyx ), bimekizumab ( Bimzelx ), guselkumab ( Tremfya ), risankizumab ( Skyrizi ), ustekinumab ( Stelara ) or ixekizumab ( Taltz )

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8 , e1000368 (2010)