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Simultaneously, released high-valent ions like Mn 4+ /Mn 3+ /Fe 3+ underwent a redox reaction with intracellular overproduced GSH

BPC 157 is a 15-amino acid peptide fragment originally isolated from mammalian gastric juice

The review also covered three therapeutic research strategies: direct GSH depletion (leading to ferroptosis or enhanced chemotherapy sensitivity), indirect approaches targeting the tumour microenvironment, and prodrug strategies utilising elevated tumour GSH for drug activation

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The combination of dasatinib and quercetin (DQ) has completed phase 1 clinical trials for Alzheimers disease, and navitoclax is currently in phase 3 clinical trials for myelofibrosis 29,30