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Phase 2 randomized, flexible crossover, double-blinded, placebo-controlled trial of the farnesyltransferase inhibitor tipifarnib in children and young adults with neurofibromatosis type 1 and progressive plexiform neurofibromas

Reports improved structural and biomechanical outcomes in animal muscle, tendon, ligament, and bone injury models

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Notably, administering PQQ has shown beneficial effects in attenuating clinically relevant dysfunctions, such as mitochondrial dysfunction, inflammation, hyperlipidemia, and lipotoxicity

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Secondary endpoints track regional brain volumes and retinal changes, since the retina serves as a window onto central nervous system nerve damage in MS