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The main differences between the two peptides are as follows: Mechanism of Action: Tirzepatide has an affinity to the receptors of another incretin hormone called Gastric Inhibitory Peptide (GIP) and also has some affinity to the GLP-1 receptors

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While calcium responses to the first on step were identical in both protocols, the amplitude of the second pulse, following a short offstep interval, was lower (Fig 6C), in agreement with the experimental results (Fig 4A)

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