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In patients with type 2 diabetes, treatment with semaglutide resulted in the following relative reductions in glucagon compared to placebo, fasting glucagon (8%), postprandial glucagon response (14 to 15%), and mean 24-hour glucagon concentration (12%)
This means that compounded semaglutide products are no longer permitted under current regulations
Dosing was continued for an additional 2 weeks to ensure drugdrug interactions were assessed at semaglutide steady state (Fig
Clin Drug Investig 2008;28(8):495-500
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Human studies are important but still depend on specific trial designs and development-stage evidence
