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These folding metastable conformers of insulin exhibited a native-like topology with 63% native hydrophobic contacts, and corroborated well with the experimental data obtained from spectroscopic, crystallographic, and calorimetric measurements during early stages of insulin aggregation

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It also suppresses NF-kB activation and modulates macrophage polarization toward an M2 anti-inflammatory phenotype

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(122) had previously demonstrated presynaptic effects of PregS