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Gastrointestinal side effects such as nausea, vomiting, or diarrhoeamay temporarily affect how well patients tolerate the medication and whether dose escalation proceeds as planned

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Tirzepatide enhances weight loss with sustained treatment but discontinuation leads to regain

13 In the SURPASS-4 trial (phase III), participants taking tirzepatide showed a much lower occurrence of composite kidney endpoint (time to first occurrence of eGFR decline of at least 40% from baseline, end-stage kidney disease, death due to kidney failure, or new onset albuminuria) compared with those who received insulin glargine (HR 0.58)

Effects of Shulikang Capsule on heart rate of young men exposed rapidly to high altitude

J Clin Transl Res