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Because ceftriaxone was never administered to asymptomatic patients, we hypothesized that it was primarily initiated empirically in cases of suspected CNS infections of unclear etiology in line with the guideline recommendations on acute bacterial meningitis [39] and subsequently continued once neurosyphilis was diagnosed
The FDA has flagged these as different active ingredients from the approved base whose safety and efficacy in humans have not been established
P., Siskind, D
10.1128/IAI.05913-11 Infect
Cells 8 , 828 (2019)
So the practical takeaway is not oral is better or SC is better. It is: pick one route, follow the documented per-dose figure for the vial you have, and keep the route constant so that whatever you observe is not confounded by a mid-stream route change
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