And a crucial point: never freeze a reconstituted glutathione solution
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As expected, KIF11 -depleted cells exhibited enhanced ferroptosis, with reduced xCT, PCBP1, GPX4, and SLC3A2 expression, increased lipid peroxidation, and elevated cell death (Supplementary Fig
We outline new mechanistic concepts, future therapeutic opportunities, potential for differentiation from currently available medicines and areas of uncertainty requiring additional investigation