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PMID: 31574939
DSIP Research Applications DSIP is studied in sleep physiology and chronobiology research, including delta-wave sleep architecture, hypothalamic-pituitary-axis interactions, cortisol and ACTH modulation, opioid receptor pathway research, and free-radical scavenging activity
It is an imbalanced agonist with GIPR potency close to native GIP but weaker GLP-1R affinity, and shows biased GLP-1R signaling, favoring cAMP over -arrestin recruitment
cAMP signaling through Gs-coupled receptors activates protein kinase A (PKA) and exchange protein directly activated by cAMP (EPAC) signals to potentiate insulin or GLP-1 secretion in pancreatic -cells 29 or intestinal L-cells 30,31
The mechanism involves sympathetic nervous system activation and direct stimulation of gut hormone release
Clin Pharmacokinet 51:553572 Rau TF, Lu Q, Sharma S, Sun X, Leary G, Beckman ML, Hou Y, Wainwright MS, Kavanaugh M, Poulsen DJ, Black SM (2012) Oxygen glucose deprivation in rat hippocampal slice cultures results in alterations in carnitine homeostasis and mitochondrial dysfunction
