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Cochrane database Syst

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Therefore, some of these findings would corroborate that UA may be a modifiable factor in the progression of chronic kidney disease, without sufficient data to state whether the beneficial effect of allopurinol is due to the reduction of UA or to the antioxidant effect produced by inhibiting the xanthine oxidase enzyme, however, the two large randomized clinical trials do not offer positive results so there is insufficient evidence to recommend allopurinol treatment in patients with asymptomatic hyperuricemia

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It is interesting to note that some of the Long COVID individuals, namely those with less severe symptoms and lowered ANTIOX without changes in OSTOX, showed increased inflammation during acute COVID-19