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Free Rad Biol Med 31, 13881395
After first use, pens can be stored at room temperature (up to 86F/30C) or refrigerated, and should be discarded after 56 days
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The medication activates GLP-1 receptors in the brain, regulating hunger cues and reducing the dopamine reward from high-sugar or high-fat foods
GLP-1 cardiovascular outcomes Multiple large-scale cardiovascular outcomes trials have demonstrated that GLP-1 agonists reduce the risk of major adverse cardiovascular events, including heart attack, stroke, and cardiovascular death
In the Phase 2 trial published in the New England Journal of Medicine (Jastreboff et al., 2023), 338 adults with obesity took retatrutide for 48 weeks
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