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Prior to working in DMEPA I, CDR Oguntimein worked in various offices at FDA

That last effect, called delayed gastric emptying, is the one that drives both the appetite suppression and most of the unpleasant GI side effects, per the Wegovy prescribing information from the FDA

Metabolic assays Isolated lung activated ILC2s were cultured in RPMI 1640 with 5% FBS, 2 mM L-glutamine, 100 U/ml Pen-Strep in addition to rmIL-2 (10ng/mL) and rmIL-7 (10ng/mL) at 37 C

10.1152/ajpgi.00183.2002 Am J Physiol Gastrointest Liver Physiol

These multisystem benefits create a healthcare ROI calculation where GLP-1 therapy prevents conditions with substantially higher lifetime treatment costs than the drug itself

Regardless of the cause, the pattern remains consistent: expect worse nausea initially, but know it typically resolves