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In addition, TMAO induces several inflammatory pathways, which cause the activation of pro-inflammatory cytokines such as IL-6 and TNF- which causes chronic inflammation thereby causing plaque formation and plaque rupture leading to cardiovascular disease [71]

SNAC has previously been co-formulated with heparin, ibandronate and vitamin B12, leading to increased systemic bioavailability of these compounds after oral administration in humans [6,7,8]

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