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23 The STEP-HFpEF and STEP-HFpEF-DM trials randomised patients with HFpEF and an LVEF 45% to oral semaglutide or placebo
doi: 10.1016/S1262-3636(17)30070-8 196 DongZZhuangQYeXNingMWuSLuLet al
But the mechanistic rationale is strong, the safety profile appears favorable, and the early observational data aligns with what the biochemistry predicts
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The data are correlative, and therefore no cause-and-effect determinations can be made
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