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10.1016/j.it.2006.11.004 Trends Immunol
cAMP activates PKA and Epac-2 signal transduction pathways, PKA and Epac-2 lead to the closure of ATP-sensitive potassium channels, which in turn causes depolarization of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of insulin granules and blood glucose control of T2DM patients
doi: 10.2337/dc11-s231 28 GallwitzB
The Notch1-Hes1 signaling pathway regulates cell differentiation, proliferation, and apoptosis
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