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The 10 structural models with the lowest associated energy from 1000 calculated structural models were used to prepare figures using the PyMOL Molecular Graphics System, Version 2.4 (Schrdinger, LLC)

The whole routine is 2-3 drops in under 30 seconds

For dark hair: suitable up to 30% grey hair, for people with light brown to black hair

Key finding: AOD 9604 reduced body weight by 5.4 kg, reduced fasting glucose by 23 mg/dL, and improved HbA1c by 0.6%

All the experiments were performed in triplicate