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Many bodybuilders report using 4 to 6 IU per day for muscle gain, a range associated with measurable IGF-1 elevation but also sharply higher risk of acromegalic side effects, carpal tunnel syndrome, and insulin resistance

Hydroxyproline (detected in comparatively reduced amounts in the barren urchins under study) and proline contribute to collagen synthesis and tissue repair, regulation of polyamine production, enhancement of protein synthesis, and scavenging of free radicals 78

Journal of Orthopaedic Research

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