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(Source: ASMBS, 2025) The researchers own conclusion is worth stating plainly: GLP-1 patients may need to adjust their expectations, adhere more closely to treatment, or opt for metabolic and bariatric surgery to achieve desired results. This isnt a case against GLP-1 therapy its a case for the structured, physician-supervised adherence support that determines whether patients get the results the clinical trials show are possible

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Probiotics Antimicrob Proteins 12:798808

Semaglutide has been used by millions of patients since 2021 for weight loss, and since 2017 in its lower-dose diabetes form (Ozempic)

Statistics indicate that the risk of lower extremity amputation is 1540 times higher in diabetic patients compared to non-diabetics, with about one million patients undergoing amputation surgeries annually due to foot complications, imposing a heavy burden on patients, families, and healthcare systems (Senneville et al., 2024)

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