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Neuschwander-Tetri BA, Loomba R, Sanyal AJ, Lavine JE, Van Natta ML, Abdelmalek MF, Chalasani N, Dasarathy S, Diehl AM, Hameed B, Kowdley KV, McCullough A, Terrault N, Clark JM, Tonascia J, Brunt EM, Kleiner DE, Doo E (2015) Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

It provides a highly effective, clinically viable alternative that bypasses hepatic first-pass metabolism, specifically designed to maximize adherence

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doi: 10.1177/1535370215584937 80 MouannessMMerhiZ

In addition, the serosal mesothelium, which covers the gut, is a major source of gut vasculature smooth muscle cells