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GLP-1 receptor agonists slow gastric emptying and suppress appetite, which can reduce energy intake and cause fatigue Fatigue is most common during initial weeks and dose increases, often improving as the body adapts over several weeks to months Nutritional deficiencies in protein, iron, vitamin D, and B vitamins may develop when food intake drops significantly Optimising nutrition with nutrient-dense foods, maintaining hydration, and gentle physical activity can significantly reduce tiredness Contact your GP if fatigue is severe, worsening, or accompanied by signs of dehydration, hypoglycaemia, or persistent gastrointestinal symptoms Table of Contents Why GLP-1 Medications Can Cause Tiredness Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly prescribed medications for type 2 diabetes and weight management, including semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)
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Experimental and Clinical Endocrinology & Diabetes
Important: The starting dose (2.5 mg) is for starting the treatment only and is not used for glycemic control
They slow digestion and lower glucagon levels by binding to GLP-1 receptors
A 2025 review in Medicina further examined how incretin-based therapy affects skeletal muscle health, highlighting that GLP-1 medications can affect muscle mass (PMID: 41011082)
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