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The main concern is stacked GI side effects - both compounds slow digestion through different pathways, so combining them can amplify nausea, vomiting, and constipation

What a Peptide Is, in Simple Terms A protein is like a huge Lego sculpture made of thousands of amino-acid bricks. Protein and the amino acids its built from are what your body uses to repair and rebuild soft tissue

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Journal of Clinical Endocrinology and Metabolism, 105(8), e2710-e2716

Cardiovascular Effects Salmeterol, the long-acting beta-agonist in Advair HFA, can affect the heart and blood vessels