One hypothesis is that Ozempics effect on slowing gastric emptying may overstimulate the gastrocolic reflex, which triggers the colon to move contents along the digestive tract more quickly, resulting in diarrhea
Additionally, the expression of tight junction-associated proteins in colonic tissues was significantly upregulated after the intervention, suggesting that the intervention may attenuate damage to intercellular tight junctions triggered by inflammatory factors, thereby protecting the intestinal mucosal barrier integrity
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) work in part through delaying gastric emptying, raising concerns about retained gastric contents (RGC) during esophagogastroduodenoscopy (EGD), Stephen A
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