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The histidine residue coordinates Cu with high affinity, forming a bioactive complex found in human plasma, saliva, and urine

Warning signs to watch for include: Severe allergic reactions Swelling of the face, lips, or throat, hives, or difficulty breathing may signal anaphylaxis, a medical emergency

Additional proposed mechanisms include improved myocardial energetics, reduced inflammation, and attenuation of cardiac remodeling, although the relative contribution of each pathway remains uncertain [33,34,35]

Some researchers also keep a marker on hand to label the vial with the reconstitution date

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Nowson CA, OConnell SL, et al