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Blood levels peak around age 20 at approximately 200 ng/mL and decline to roughly 80 ng/mL by age 60, correlating with diminished skin elasticity and regenerative capacity
This metabolite has been shown to deplete glutathione, induce oxidative stress, and cause mitochondrial injury, even in the absence of hepatic toxicity
Loren Pickart estimated the lethal dose at approximately 22,500 mg for humans, which is 300-fold above effective doses
If you are concerned about varicose veins, talk to your doctor
Barnes BJ and Hollands JM Drug-induced arrhythmias. Crit Care Med 38 (2010): S188-197
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