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Patients should be questioned about their adherence to therapy (such as whether or not they are taking this medication as prescribed) before their dosage is increased A dose of 2 mg/kg per day may be necessary for patients with very severe acne, scarring, or primary symptoms on the trunk

Treatment plans vary per individual Results may take time and consistency Medical supervision is important Peptide therapies discussed may not be FDA-approved for all uses

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376 Additionally, endoscopic ablation techniques, especially radiofrequency ablation (RFA), have become the main approach for treating BE with dysplasia, particularly for flat lesions