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Not approved for human therapeutic use

described a patient with a novel BCS1L mutation who had slower disease progression, presenting with myopathy, focal motor seizures, and optic nerve atrophy (88)

[1] [2] Clinicians should counsel patients about the importance of fluid intake and monitor for symptoms suggestive of nephrolithiasis, particularly in individuals with pre-existing risk factors for kidney stones

Patients taking insulin or sulfonylureas alongside semaglutide face increased hypoglycemia risk

This could be considered in future therapies

Within clinical trials, dose adjustment is managed entirely by the supervising research team in accordance with the trial protocol