An obvious prerequisite for cell cycle progression is the synthesis of new DNA fueled by adequate supply of nucleotides, and here is where folates (tetrahydrofolate, THF) come into the picture
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"Nutritional and therapeutic properties of Urtica dioica." Journal of Herbal Medicine , 2016
In breast cancer, transcription factor AP-2 gamma (TFAP2C) is an important transcription factor that regulates estrogen receptor-alpha (ER) and c-ErbB2/HER2 (Her2), which are involved in the establishment of the gene expression pattern observed in different clinical phenotypes of breast cancer [79, 80]
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