33 El MessariS.LeloupC.QuignonM.BrisorgueilM.-J.PenicaudL.ArluisonM
The angiotensin AT4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer's disease
In metastatic colorectal cancer tissues, studies indicate that elevated H3K27cr levels are significantly associated with advanced disease stages
In the regulation of ferroptosis, different PTMs can be interconnected and influence each other through specific proteins as targets
Although AD and VaD share common vascular risk factors, the contribution of small artery disease to VaD pathogenesis may be greater than that of AD [120].In fact, studies have found that neuropathic changes can be evident 20 years before the onset of dementia and that there is a substantial neuronal loss in the MCI stage, which is considered a transitional state before the onset of dementia [121]
That these relationships were seen in hepatocytes, myocytes, and brown adipocytes, but were conspicuously absent in fibroblasts, hints that oxidative metabolism might represent an intrinsic challenge to ER functionality and might explain why feeding itself appears to be an ER stressor